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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB6031 |
| Description | Anti-Integrin alpha-11 Antibody |
| Alternate Names |
|
| Background Information | Integrin alpha-11 (ITGA11) belongs to a family of cell adhesion molecules, which consist of noncovalent associated alpha-beta heterodimers, and is shown to be overexpressed in the stroma of human non-small-cell lung carcinomas (hNSCLCs). Upon dimerization, this protein is thought to enhance tumorgenicity of hNSCLCs by interacting with matrix collagen and stromal fibroblasts. Progesterone is shown to increase the expression of ITGA11 through mid-gestation and decrease thereafter in Sprague-Dawley rats. It is further indicated that MAPK signaling is associated with the regulation of these integrins. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Linear peptide corresponding to human Integrin alpha-11. |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Species Reactivity |
|
| Species Reactivity Note | Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. |
| Gene Symbol |
|
| Purification Method | Affinity Purfied |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen. SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21. SUBCELLULAR LOCATION: Membrane. Note: Single-pass type I membrane protein. |
| Molecular Weight | ~135 kDa observed. The high molecular weight band seen in a HeLa (non boiled) cell lysate is the integrin complex. The band at ~75-80 kDa is thought to be a denatured form of integrin. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected Integrin alpha-11 in 10 µg of non-boiled & non-B-ME HeLa cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |