We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cell Signaling Caspase-7 (D2q3l) Rabbit mAb
Cell Signaling Caspase-7 (D2q3l) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$139.00
Your Price
$139.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CSIG-12827T |
MFG.PART: | 12827T |
UNSPSC: | 12352202 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H M R |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 20, 35 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Caspase-7 (D2Q3L) Rabbit mAb recognizes endogenous levels of total caspase-7 protein. This antibody detects both the full-length (35 kDa) and large (20 kDa) subunits following caspase-7 activation. |
Species Reactivity | Human, Mouse, Rat |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro158 of human caspase-7 protein. |
Background | Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5). |
SKU | CSIG-12827T |
---|---|
Supplier Part Number | 12827T |
UM | UNIT |
UNSPSC | 12352202 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |