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Cell Signaling Caspase-7 Antibody
Cell Signaling Caspase-7 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$129.00
Your Price
$129.00
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NETA PART: | CSIG-9492T |
MFG.PART: | 9492T |
UNSPSC: | 12352202 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H M R Mk |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 20, 35 |
Source/Isotype | Rabbit |
Application/Dilution | {Western Blotting: 1:1000, Simple Western™: 1:100 - 1:250} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Caspase-7 Antibody detects endogenous levels of both full length caspase-7 (35 kDa) and the large fragment of cleaved caspase-7 following cleavage at aspartic acid 198 (20 kDa). The antibody does not recognize other caspases. |
Species Reactivity | Human, Mouse, Rat, Monkey |
Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the cleavage site of human caspase-7. Antibodies are purified by protein A and peptide affinity chromatography. |
Background | Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5). |
SKU | CSIG-9492T |
---|---|
Supplier Part Number | 9492T |
UM | UNIT |
UNSPSC | 12352202 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |