Cayman Triphenylphosphine Oxide; Purity- Greater Than Or Equal To

TGN 020 is an aquaporin-4 (AQP4) inhibitor (IC₅₀ = 3.1 μM in X. laevis oocytes transfected with AQP4). It reduces brain edema and cortical infarction size in a mouse model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 200 mg/kg. TGN 020 (200 mg/kg every 6 hours) reduces bronchoalveolar lavage fluid (BALF) IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury.

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