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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| R | IHC | Gp | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB10556 |
| Description | Anti-mGluR8 Antibody |
| Alternate Names |
|
| Background Information | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Unpurified guinea pig polyclonal serum with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-mGluR8 Antibody detects level of mGluR8 & has been published & validated for use in IH. |
| Key Applications |
|
| Application Notes | Evaluated by Western Blot in rat brain lysate. Although intended for use in IHC analysis, a band was observed at ~101kDa. |
| Biological Information | |
|---|---|
| Immunogen | This antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8. |
| Epitope | Cytoplasmic Domain |
| Host | Guinea Pig |
| Specificity | This antibody recognizes mGluR8. |
| Species Reactivity |
|
| Species Reactivity Note | Predicted to react with human, chimpanzee, monkey, dog, cow and mouse based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene |
| Gene Symbol |
|
| Purification Method | Unpurified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. SUBUNIT STRUCTURE: Interacts with PICK1 By similarity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family. |
| Molecular Weight | 101 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Immunohistochemistry Analysis: : 1:100-500 dilution from a previous lot detected mGluR8 on rat brain tissue. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |