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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | IHC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB10557 |
| Description | Anti-Lhx2 Antibody |
| Alternate Names |
|
| Background Information | LIM homeobox 2, also known as LHX2, is a gene that belongs to the LIM homeobox family. These genes seem to play an important role in asymmetric cell division, tissue specification and differentiation of specific cell types. LHX2 is expressed in developing B-cells, the forebrain, liver, during embryonic development when limbs and organs are developing, in the optic stalk, and olfactory epithelia. Studies have shown that under-expression of LHX2 during embryonic development causes hepatic fibrosis. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Lhx2 Antibody is validated for use in IH for the detection of Lhx2. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues of human LHX2. |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | This antibody recognizes LHX2. |
| Species Reactivity |
|
| Species Reactivity Note | Demonstrated to react with human. Expected to react with horse, dog, and cow (93%) homology. Mouse (80%) homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Affinity Purfied |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types By similarity. SUBCELLULAR LOCATION: Nucleus Probable. SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. |
| Molecular Weight | Approx. 44 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Immunohistochemistry in human hippocampal and mouse cerebellum tissue. Immunohistochemistry Analysis: 1:100-500 dilution of this lot detected LHX2 in human hippocampal tissue and mouse cerebellum. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain refrigerated at 2-8°C for up to 12 months. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |