Cell Signaling Cdk6 (Dcs83) Mouse mAb

Name: Cell Signaling Cdk6 (Dcs83) Mouse mAb
SKU: CSIG-3136T
Price: 144.43 USD

List Price $144.43 Your Price $144.43

Cell Signaling Cdk6 (Dcs83) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3136T

MFG.PART: 3136T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	36
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:2000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CDK6 (DCS83) Mouse mAb detects endogenous levels of total CDK6 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human CDK6 corresponding to amino acids 30-65.
Background	The cyclin-dependent kinases form complexes with their cyclin partners and with CDK inhibitors. CDK6 and CDK4 associate with the D-type cyclins and target the retinoblastoma protein, allowing passage through the G1/S phase restriction point (1). CDK6/cyclin D complexes are sequestered in their inactive form through binding to one of the INK4 CDK inhibitor family members (2,3). Unlike the INK4 family of CDK inhibitors, the CDK inhibitor p21 Waf1/Cip1 may enhance the association of CDK4 and CDK6 with their cyclin D partners (4).

Specifications