Cell Signaling Phospho-Npm (Ser4) (D19c1) Xp Rabbit mAb

Name: Cell Signaling Phospho-Npm (Ser4) (D19c1) Xp Rabbit mAb
SKU: CSIG-3520T
Price: 210.08 USD

List Price $210.08 Your Price $210.08

Cell Signaling Phospho-Npm (Ser4) (D19c1) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3520T

MFG.PART: 3520T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	38
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Flow Cytometry (Fixed/Permeabilized): 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-NPM (Ser4) (D19C1) XP® Rabbit mAb detects endogenous levels of NPM only when phosphorylated at Ser4.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser4 of human NPM. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities (1,2). The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase (3,4).

Specifications