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Cell Signaling Cyclin A2 (Bf683) Mouse mAb
Cell Signaling Cyclin A2 (Bf683) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$138.00
Your Price
$138.00
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NETA PART: | CSIG-4656T |
MFG.PART: | 4656T |
UNSPSC: | 41116111 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 55 |
Source/Isotype | Mouse IgE |
Application/Dilution | {Western Blotting: 1:2000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Cyclin A2 (BF683) Mouse mAb detects endogenous levels of cyclin A2 and does not cross-react with other cyclins or Cyclin A1. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a recombinant human cyclin A2 protein. |
Background | While overcoming the G1/S checkpoint to commence DNA replication requires cyclin E, and traversing the G2/M checkpoint to initiate mitosis requires cyclin B to be present, cyclin A seems to be required for both S-phase and M-phase (1). A number of studies have described the ability of overexpressed cyclin A to accelerate the G1 to S transition causing DNA replication, and cyclin A antisense DNA can prevent DNA replication (2-4). Cyclin A availability is apparently the rate-limiting step for entry into mitosis, and cyclin A is required for completion of prophase (5). At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active (5). |
SKU | CSIG-4656T |
---|---|
Supplier Part Number | 4656T |
UM | UNIT |
UNSPSC | 41116111 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |