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Cell Signaling Wrn (8h3) Mouse mAb
Cell Signaling Wrn (8h3) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$155.00
Your Price
$155.00
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| NETA PART: | CSIG-4666T |
| MFG.PART: | 4666T |
| UNSPSC: | 41116111 |
| Manufacturer: | Cell Signaling |
| Size | 20 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 200 |
| Source/Isotype | Mouse IgG1 |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | WRN (8H3) Mouse mAb detects endogenous levels of total WRN protein. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with full length human recombinant WRN protein. |
| Background | The RecQ family of DNA and RNA helicases is a family of enzymes that has been shown to be important to genome integrity (1). Members of this family function in several DNA repair processes including double strand break repair, homologous recombination, and re-initiation of DNA replication at stalled replication forks (2,3). Mutations in RecQ helicase family members results in syndromes that display varying types of chromosomal abnormalities and overall genomic instability (1). WRN is a member of the RecQ family that has been identified as the gene underlying Werner’s syndrome; an autosomal recessive disorder characterized by premature aging and predisposition to cancer (4). Cells from Werner’s Syndrome patients exhibit genomic instability that is associated with deficient DNA repair activity (5). |
| SKU | CSIG-4666T |
|---|---|
| Supplier Part Number | 4666T |
| UM | UNIT |
| UNSPSC | 41116111 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |