Miltenyi Biotec Recombinant Sars-Cov-2 Spike-Trimer (Hek)-Biotin; 25 µg

Miltenyi Biotec The SARS-CoV-2 Spike (S) glycoprotein mediates the entry of the virus into target cells via its interaction with the angiotensin-converting enzyme 2 (ACE2) receptor, thereby initiating the infection. It forms a homotrimeric structure on the surface of the SARS-CoV-2 virus and represents the major target for diagnostic and therapeutic agents. The ectodomain of the S glycoprotein comprises the N-terminal S1 subunit, including the receptor binding domain, and, the C-terminal S2 subunit. | SARS-CoV-2 Spike-Trimer (HEK) protein covers the ectodomain of the viral surface protein including amino acids V16 to K1211 and contains the stabilizing proline substitutions at position K986P and V987P as well as a mutated Furin cleavage site (RRAR to GSAS substitution at residues 682–685). A T4 fibritin trimerization motif induces the conformation of a highly stable native-like homotrimer. The protein is extended at its C-terminus with a His-tag and an AviTagTM. - MLTY (Additional S&H or Hazmat Fees May Apply)