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Nectins are immunoglobulin superfamily adhesion molecules that participate in the organization of epithelial and endothelial junctions. Human and mouse NECL1 share 87.3% identity at the amino acid level (1). NECL1 contains an ectodomain made of three immunoglobulin-like domains, and a cytoplasmic region homologous to those of glycophorin C and contactin-associated protein. NECL1 predominantly expressed in the central nervous system, mainly in neuronal cell bodies in a variety of brain regions including the cerebellum, cerebral cortex and hippocampus. NECL1 localizes to the cell-cell junctions and recruits protein 4.1N to the plasma membranes through its C-terminus, thus may regulate the function of the cell-cell junction.
Product Information
Format
Affinity Purified
Control
Tested on Adult mouse brain lysate
Presentation
Purified Antibody in PBS with 0.1% NaN3
Quality Level
MQ100
Applications
Application
Detect NECL-1 using this Anti-NECL-1 Antibody validated for use in IH & WB.
Key Applications
Immunohistochemistry
Western Blotting
Application Notes
Western Blot Analysis: NECL-1 can be detected at 1/500 dilution. Testing at further dilution was not conducted.
Immunohistochemistry: 1:50 to 1:1000 straight dilution of Cat. # AB15301 was tested on human medulla oblongata tissue.
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Synthetic Peptide
Host
Rabbit
Specificity
NECL-1
Species Reactivity
Mouse
Antibody Type
Polyclonal Antibody
Gene Symbol
CADM3
IGSF4B
NECL1
SYNCAM3
TSLL1
Purification Method
ImmunoAffinity Purified
UniProt Number
Q8N126
Molecular Weight
43 kDa
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
