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Millipore Detect Endothelin-1 Using This Anti-Endothelin-1 Antibody, Clone Ic4 Validated For Use In Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells
Presentation
Liquid in 0.02 M PBS with 0.25 M NaCl, pH 7.6. Contains 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Detect Endothelin-1 using this Anti-Endothelin-1 Antibody, clone IC4 validated for use in IHC.
Key Applications
Immunohistochemistry
Application Notes
Development of Immunoradiometric assay (IRMA) for endothelin ET-1 which as a circulating plasma peptide has been associated with a variety of disease studies such as diabetes, hypertension, cardiogenic shock, acute myocardial infarction and uraemia.
Suitable for immunohistochemistry on frozen sections
Optimal working dilutions must be determined by the end user.
Biological Information
Clone
IC4
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
Recognizes endothelin ET-1 (10% cross-reactivity with ET-3) and when used in conjunction with CBL87 (anti-endothelin C-terminus) has a sensitivity of 0.06 pmol/L for ET-1.
Isotype
IgG1
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_001955.3
Gene Symbol
EDN1
OTTHUMP00000039245
Preproendothelin-1
ET1
PPET1
ET-1
HDLCQ7
Purification Method
Protein A Purfied
UniProt Number
P05305
UniProt Summary
FUNCTION: SwissProt: P05305 # Endothelins are endothelium-derived vasoconstrictor peptides. SIZE: 212 amino acids; 24425 Da SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. SIMILARITY: SwissProt: P05305 ## Belongs to the endothelin/sarafotoxin family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
For use within 1 month of purchase when stored at +4°C, for long-term storage, aliquot antibody into small volumes and store at -20°C.
