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Purified Human Tenascin-C Protien. Tenascin is known to: 1) play an active role in development of central nervous system and mesenchymal-derived organs; 2) exist in vasculature of tumors in adults; and 3) function in cell adhesion. By SDS-PAGE analysis, the protein migrates around 280-300kD.
Alternate Names
TN-C
Tenascin
Hexabrachion
Cytotactin
Neuronectin
Product Information
Presentation
Purified protein supplied as a liquid in PBS containing no preservatives.
Quality Level
MQ100
Applications
Key Applications
Positive Control
Cell Culture
Application Notes
Cell adhesion assays.
Optimal working dilutions must be determined by end user.
Biological Information
Concentration
0.1 mg/mL
Purity
> 97% pure by SDS-PAGE
Source
Human glioma cell line (U251).
Entrez Gene Number
NM_002160.2
Gene Symbol
TNC
Hexabrachion
HXB
GMEM
TN
Neuronectin
Tenascin-C
MGC167029
JI
TN-C
Cytotactin
UniProt Number
P24821
UniProt Summary
FUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. SIZE: 2201 amino acids; 240866 Da SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. PTM: N-glycosylated (By similarity). SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
Stem Cell Type
Human Embryonic Stem Cells
Mesenchymal Stem Cells
Neural Stem Cells
Hematopoietic Stem Cells
Epithelial Cells
Pancreatic Stem Cells
Induced Pluripotent Stem Cells
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -70ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
UM-SCC-104 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
