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Cell Signaling Ets-1 (D8o8a) Rabbit mAb
Cell Signaling Ets-1 (D8o8a) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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NETA PART: | CSIG-14069S |
MFG.PART: | 14069S |
UNSPSC: | 41116113 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M R |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 52 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:2000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:3200 - 1:6400, Chromatin IP: 1:50, Chromatin IP-seq: 1:50, CUT&RUN: 1:50} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | ETS-1 (D8O8A) Rabbit mAb recognizes endogenous levels of total ETS-1 protein. |
Species Reactivity | Human, Mouse, Rat |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser179 of human ETS-1 protein. |
Background | ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence (ETS) family of transcription factors that share a unique and highly conserved DNA binding domain (1). ETS-1 plays important roles in vascular development and angiogenesis (2), and vascular inflammation and remodeling (3). The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecules (4-6). In addition, ETS-1 is involved in regulation of energy metabolism in cancer cells (7). ETS-1 activity is regulated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity (8), phosphorylation at its Thr38 site by Ras activates ETS-1 (9). |
SKU | CSIG-14069S |
---|---|
Supplier Part Number | 14069S |
UM | UNIT |
UNSPSC | 41116113 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |