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Protein A affinity chromatography resin is the most commonly applied method for the isolation and purification of IgG. Protein A is a cell wall component found in several strains of Staphylococcus aureus. It has five high affinity binding sites capable of binding specifically to the Fc region of immunoglobulin molecules from several species. Covalently immobilized Protein A matrices have been extensively used to purify IgG from several species of mammals.
GenScripts Monofinity A Resin is made of recombinant protein A as ligand, which not only keeps the specific binding capacity to Fc region of immunoglobulin molecules, but also enhances chemical stability under Cleaning-in-place (CIP) conditions. The typical dynamic binding capacity is more than 30 g human IgG/L settled resin. There is no significant decrease of binding capacity after purification/CIP for 200 cycles. In the meanwhile, the Monofinity A Resin has a low leakage of ligand (< 15 ng ligand/mg IgG) over a number of purification/CIP cycles.
As a high quality antibody purification resin, it is highly suitable for large scale antibody purification, and meets the purification requirements of industry-scale customers.
Product Details
Cat.No.
Product Name
Volume supplied
Resin content
L00433-55
Monofinity A Resin Prepacked Column (5mlx5)
5 ml x 5
Prepacked column
L00433-51
Monofinity A Resin Prepacked Column (5mlx1)
5 ml x 1
L00433-11
Monofinity A Resin Prepacked Column (1mlx1)
1 ml x 1
L00433-15
Monofinity A Resin Prepacked Column (1mlx5)
1 ml x 5
L00433-25
Monofinity A Resin (25ml)
50 ml
50% slurry
L00433-200
Monofinity A Resin (200ml)
400 ml
50% slurry
L00433-1
Monofinity A Resin (1L)
2 L
50% slurry
L00433-5
Monofinity A Resin (5L)
10 L
50% slurry
L00433-10
Monofinity A Resin (10L)
20L
50% slurry
Overview
Key Features
Key Features
High dynamic binding capacity: >30 mg IgG/ml settled resin
High recovery rate: >97% in average
Enhanced stability: good thermal and chemical stability
Low ligand leakage: < 15 ng/mg IgG
Reliable scale-up: highly suitable for large scale antibody purification
Alkaline tolerance: Clean in place with 0.1 M NaOH
Properties
Storage & Stability
Store in binding/ washing buffer containing 20% ethanol at 2-8°C
Do NOT freeze
Applications
Applications
Laboratory scale antibody purification
Bioprocess scale antibody purification
Storage
Store in binding/ washing buffer containing 20% ethanol at 2-8°C.Do NOT freeze
