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Biacore sensor chip for orientation-specific binding of antibodies (predominantly human) through Fc-region.
With MabSelect SuRe ligand on the surface.
Site-directed capture of antibody: binds predominantly to the heavy chain within the Fc region and ensures antibodies are bound to the surface in a specific orientation.
Time and effort savings: ready-to-use sensor chip eliminates the need to develop immobilization and regeneration conditions.
Confidence in data: highly controlled development processes and manufacturing conditions ensure reproducible results.
Surface description
Carboxymethylated dextran matrix with a recombinant Protein A variant covalently attached. The surface ligand is the same as is used for our MabSelect SuRe protein purification products.
Binds antibodies from several mammalian species, most notably human antibodies of the subclasses IgG1, IgG2, and IgG4.
Binds only to the heavy chain within the Fc region, ensuring a specific orientation of the antibody on the surface.
Does not bind Fab fragments (unlike native Protein A).
Sensor chip formats for Biacore systems
Biacore sensor chips are available in two formats.
Series S sensor chips are for use with Biacore 1 series, Biacore 8 series, Biacore S200, Biacore T200, and Biacore 4000 SPR systems.
Sensor chips not designated with series S are designed for Biacore X100, and Biacore C SPR systems.
Convenient antibody analysis in Biacore systems
Sensor Chip Protein A is a sensor surface pre-immobilized with a recombinant Protein A variant binding antibodies for protein interaction analysis using Biacore systems. It is ready-to-use with high binding capacity offering a wide dynamic range and high convenience, reproducibility, and robustness. Sensor Chip Protein A is an excellent surface choice for antibody quantitation and characterization in biopharmaceutical late stage development and manufacturing QC.
