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20 mM MOPS, pH 7.2; 25 mM b-glycerol phosphate; 5 mM EGTA; 1 mM sodium orthovanadate; 1 mM dithiothreitol
Quality Level
MQ300
Applications
Application
Casein Kinase 2 Substrate Peptide primarily used in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Entrez Gene Number
NM_001320.5
Entrez Gene Summary
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.
Gene Symbol
CSNK2B
Phosvitin
CK2B
CSK2B
MGC138224
MGC138222
CK2N
G5a
phosvitin
G5A
Protein Target
CK2
Target Sub-Family
CMGC
UniProt Number
P67870
UniProt Summary
FUNCTION: SwissProt: P67870 # Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. SIZE: 215 amino acids; 24942 Da SUBUNIT: Tetramer composed of an alpha subunit, an alpha subunit and two beta subunits. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. PTM: Phosphorylated by alpha subunit. SIMILARITY: SwissProt: P67870 ## Belongs to the casein kinase 2 subunit beta family.
Product Usage Statements
Quality Assurance
Routinely evaluated as a substrate in a kinase assay.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of the product, centrifuge the original vial prior to removing the cap.
