| Description | |
|---|---|
| Catalogue Number | 12-516 |
| Brand Family | Upstate |
| Trade Name |
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| Description | Axltide |
| Product Information | |
|---|---|
| Presentation | Lyophilized powder |
| Quality Level | MQ300 |
| Applications | |
|---|---|
| Key Applications |
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| Biological Information | |
|---|---|
| Entrez Gene Number |
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| Entrez Gene Summary | The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Gene Symbol |
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| Protein Target | Axl |
| Target Sub-Family | TK |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P30530 # May function as a signal transducer between specific cell types of mesodermal origin. SIZE: 887 amino acids; 97437 Da SUBUNIT: Heterodimer and heterotetramer with GAS6. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE:SwissProt: P30530 # Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. SIMILARITY: SwissProt: P30530 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated by for use as a substrate in protein kinase assay. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 1 mg |