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AG Scientific 17-DMAG, 1 MG
List Price
$76.89
Your Price
$76.89
AG Scientific 17-DMAG (1 mg) binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor (Additional S&H Or Hazmat Fees May Apply) - AG
NETA PART:
RPI-A-1298-1MG
MFG.PART:
A-1298-1MG
UNSPSC:
12352200
Manufacturer:
AG Scientific
AG Scientific
17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin and 17-AAG, 17-DMAG binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.
Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation.
HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.
| SKU | RPI-A-1298-1MG |
|---|---|
| Supplier Part Number | A-1298-1MG |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | AG Scientific |
| MSDS URL | Click here |
| Temperature | -20°C |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | USA |
| ProductLine | AG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 5.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 467214-20-6 |