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AG Scientific 17-DMAG, 1 MG
NETA PART: | RPI-A-1298-1MG |
MFG.PART: | A-1298-1MG |
UNSPSC: | 12352200 |
Manufacturer: | AG Scientific |
17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin and 17-AAG, 17-DMAG binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.
Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation.
HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.
SKU | RPI-A-1298-1MG |
---|---|
Supplier Part Number | A-1298-1MG |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | AG Scientific |
MSDS URL | https://agscientific.com/system/product_documents/A-1298%2C%2017-DMAG%2C%20SDS%202022_r01_1.pdf |
Temperature | -20°C |
Refrigerated-Frozen | Y |
CountryOfOrigin | USA |
ProductLine | AG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 5.00 |
Lead Time | 5 Business Days |
Hazardous | N |
CAS Number | 467214-20-6 |