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GenScript Pdgf-Bb, Human (P. Pastoris-Expressed); 1mg
List Price
$2,340.00
Your Price
$2,340.00
GenScript Pdgf-Bb, Human (P. Pastoris-Expressed) - GSCRPT (Additional S&H or Hazmat Fees May Apply)
NETA PART:
GSCRPT-Z02529-1
MFG.PART:
Z02529-1
UNSPSC:
41116127
Manufacturer:
GenScript USA Inc
Product Introduction
| Species | Human | |
| Protein Construction |
| |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC | |
| Endotoxin Level | < 1 EU/μg of protein by gel clotting method | |
| Biological Activity | ED50 < 3.0 ng/ml, measured by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells, corresponding to a specific activity of > 3.3 × 105 units/mg. | |
| Expression System | P. pastoris | |
| Apparent Molecular Weight | ~24.3 kDa, on SDS-PAGE under non-reducing conditions. | |
| Formulation | Lyophilized after extensive dialysis against 10 mM acetic acid. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo, PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets. |
| Synonyms | PDGFBB; IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis; platelet derived growth factor subunit B |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z02529-1 |
|---|---|
| Supplier Part Number | Z02529-1 |
| UM | EA |
| UNSPSC | 41116127 |
| Manufacturer | GenScript USA Inc |
| Temperature | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (examp |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 7 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |