Sigma-Aldrich Fmoc-Orn(Mtt)-Oh Novabioch

Quality Level

200

Product Line

Novabiochem^®

Assay

≥90.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)

Form

powder

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Manufacturer/Tradename

Novabiochem^®

Application(S)

peptide synthesis

Functional Group

amine

Storage Temp.

15-25°C

Inchi

1S/C40H38N2O4/c1-28-22-24-31(25-23-28)40(29-13-4-2-5-14-29,30-15-6-3-7-16-30)41-26-12-21-37(38(43)44)42-39(45)46-27-36-34-19-10-8-17-32(34)33-18-9-11-20-35(33)36/h2-11,13-20,22-25,36-37,41H,12,21,26-27H2,1H3,(H,42,45)(H,43,44)/t37-/m0/s1

Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

General Description

The side-chain Mtt group can be selectively removed with 1% TFA in DCM ^[1,2,3] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) , making this an excellent derivative for the synthesis by Fmoc SPPS of branched peptides, peptides modified at the ornithine side-chain ^[4,5] , for the construction of templates and multifunctionalized resins for combinatorial synthesis ^[6] .

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283.
A. Aletras, et al. (1995)Int. J. Peptide Protein Res.,45, 488.
L. Bourel, et al.(2000)J. Peptide Sci.,6, 264.
K. Barlos, personal communication.
^[5] P. Hoogerhout, et al. (1999)J. Peptide Res., 54, 436.
^[6] C. Park & K. Burgess (2001)J. Comb. Chem.,3, 257.

Linkage

Replaces: 04-12-1168

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 98 %
Purity (TLC(011C)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem^®products please click here.Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany