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Cell Signaling Ssrp1 (E1y8d) Rabbit mAb
Cell Signaling Ssrp1 (E1y8d) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$327.00
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$327.00
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NETA PART: | CSIG-13421S |
MFG.PART: | 13421S |
UNSPSC: | 41106509 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M R Mk |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 81 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000, Chromatin IP: 1:50} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | SSRP1 (E1Y8D) Rabbit mAb recognizes endogenous levels of total SSRP1 protein. This antibody also cross-reacts with protein of unknown origin at 140 kDa in some cell lines. |
Species Reactivity | Human, Mouse, Rat, Monkey |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val145 of human SSRP1 protein. |
Background | Suppressor of Ty-16 (SPT16) and structure-specific recognition protein-1 (SSRP1) are subunits of the facilitates chromatin transcription (FACT) complex that is essential for transcription elongation (1,2). FACT facilitates RNA polymerase-dependent transcription of chromatin templates by destabilizing the nucleosomes within the open reading frames of active genes (3-5). FACT destabilizes the nucleosomes, which would otherwise act as barriers to RNA polymerase transcription activity, by disrupting histone-histone and histone-DNA contacts that lead to the eviction of the histone H2A-H2B dimer (2,3,6). FACT may also function as a histone chaperone to reassemble nucleosomes after RNA polymerase passage (7). In addition to transcription, FACT activity has been shown to have a role in DNA replication in yeast and in DNA repair by contributing to the activation of p53 by CK2 and by facilitating histone H2AX-H2B exchange upon DNA damage (8,9). |
SKU | CSIG-13421S |
---|---|
Supplier Part Number | 13421S |
UM | UNIT |
UNSPSC | 41106509 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |