The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Anti-Nogo Receptor Antibody Detects Level Of Nogo Receptor & Has Been Published & Validated For Use In Wb, Ih. - Mill (Additional S&H or Hazmat Fees May Apply)
Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.
Product Information
Format
Purified
Control
Mouse cerebellum lysate
Presentation
Purified in PBS with 0.1% NaN3
Quality Level
MQ100
Applications
Application
Anti-Nogo Receptor Antibody detects level of Nogo Receptor & has been published & validated for use in WB, IH.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Non-Lot Specific Tested Application 1: Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)
Biological Information
Immunogen
Recombinant protein.
Epitope
Mature Form
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Cat. # AB15138 recognizes the mature form of Nogo Receptor.
Species Reactivity
Mouse
Rat
Human
Species Reactivity Note
Mouse and rat. May react with human and primate based on sequence homology. Reactivity with other species has not been determined.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_022982
Purification Method
Protein A Purfied
UniProt Number
Q99PI8
Molecular Weight
~50.9 kDa
Product Usage Statements
Quality Assurance
Routinely tested on mouse cerebellum lysate. Lot Specific Tested Application 1: Western Blot
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
