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Millipore This Anti-Phospho-Munc-18 (Ser515) Antibody Is Validated For Use In Wb For The Detection Of Phospho-Munc-18 (Ser515). - Mill (Additional S&H or Hazmat Fees May Apply)
Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol.
Quality Level
MQ100
Applications
Application
This Anti-phospho-Munc-18 (Ser515) Antibody is validated for use in WB for the detection of phospho-Munc-18 (Ser515).
Key Applications
Western Blotting
Biological Information
Immunogen
Synthetic peptide corresponds to sequence surrounding the phosphoserine 515 site of rat Munc-18.
Host
Rabbit
Specificity
Munc-18, phospho Serine 515. The antibody recognizes a protein of ~65 kDa corresponding to Munc-18, phospho Serine 515 in lysates from rat cortex. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide.
Species Reactivity
Rat
Species Reactivity Note
The immunogen has 100% homology with human, mouse, non-human primates, bovine, canine, chicken and Xenopus.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_013038.3
Gene Symbol
Stxbp1
Unc18a
Modifications
Phosphorylation
Purification Method
ImmunoAffinity Purified
UniProt Number
P61765
UniProt Summary
FUNCTION: SwissProt: P61765 # May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. SIZE: 594 amino acids; 67569 Da SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Brain and spinal cord. Highly enriched in axons. SIMILARITY: SwissProt: P61765 ## Belongs to the STXBP/unc-18/SEC1 family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
