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Millipore Use Anti-Musashi-1 Antibody, Clone 7b11.1 (Mouse Monoclonal Antibody) Validated In Wb, Ihc To Detect Musashi-1 Also Known As Rna-Binding Protein Musashi Homolog 1. - Mill (Additional S&H or Hazmat Fees May Apply)
In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, cellular differentiation, nuclear signaling and tumorigenesis. Musashi-1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi-1 is a selective marker for intestinal stem or early lineage cells. Musashi-1 interacts with the Notch pathway during asymmetric cell division by binding the 3 UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi-1 is present.
Product Information
Format
Purified
Control
Mouse E17 spinal cord tissue lysate.
Presentation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Use Anti-Musashi-1 Antibody, clone 7B11.1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Musashi-1 also known as RNA-binding protein Musashi homolog 1.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Western Blot Analysis: A representative lot detected Musashi-1 in HEK293, NIH/3T3, and PC-12 cell lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Musashi-1 in mouse cerebellum, normal mouse brain, and normal human pons tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Musashi-1.
Clone
7B11.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002433
Gene Symbol
MSI1
Purification Method
Protein G Purified
UniProt Number
O43347
Molecular Weight
~39 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in mouse E17 spinal cord tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Musashi-1 in 10 µg of mouse E17 spinal cord tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
