Cell Signaling Semaphorin 4b Antibody

Name: Cell Signaling Semaphorin 4b Antibody
SKU: CSIG-13771S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Semaphorin 4b Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13771S

MFG.PART: 13771S

UNSPSC: 12352200

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	95
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Semaphorin 4B Antibody recognizes endogenous levels of total semaphorin 4B protein.
Species Reactivity	Human, Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro101 of human semaphorin 4B protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The semaphorin family of proteins is involved in axon guidance, cell migration, angiogenesis, and immune response. Plexins and neuropilins bind with high affinity to semaphorins to mediate their functions. Semaphorins are divided into seven classes of secreted or membrane-bound proteins. Members of Class 4 semaphorins include 4A through 4G; semaphorin 4B is a membrane-associated protein (1,2). Semaphorin 4B binds to the CLCP1 receptor and regulates cell motility (3). Furthermore, semaphorin 4B, like many other semaphorins, has a PDZ domain-binding motif at the carboxy terminus that interacts with PSD95 and localizes to the post-synaptic membrane (4).

Specifications