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Cell Signaling P2x7 Receptor (E1e8t) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling P2x7 Receptor (E1e8t) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-13809S
MFG.PART:
13809S
UNSPSC:
12352200
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 78 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | P2X7 Receptor (E1E8T) Rabbit mAb recognizes endogenous levels of total P2X7 receptor protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu462 of human P2X7 receptor protein. |
| Background | P2X purinergic receptors are ATP-gated ion channels involved in physiological processes that include inflammation, afferent sensory signaling, and sympathetic motor nerve activity. Seven different vertebrate genes (P2RX1-P2RX7) encode for individual receptor protein subunits (1). All P2X subunit proteins share similar protein domain structure, but can differ in overall protein length from 384 to 595 amino acids. Each P2X subunit is composed of amino- and carboxy-terminal intracellular domains, two transmembrane domains, and a large extracellular loop that contains ten evenly spaced cysteines and multiple glycosylation sites (2). P2X receptors are found in a variety of cell types and tissues, including central and peripheral nervous system neurons and glial cells, autonomic and sensory neurons, bone, muscle, and hematopoietic tissues (1).Purinoceptor 7 (P2X7) is a homotrimer involved in diverse cellular responses, including inflammation mediated by phospholipase A2, phospholipase D, MAP kinase, and NF-κB activation (3,4). Research studies suggest that P2X7 receptors promote apoptosis by regulating release of IL-1β in neurodegenerative disorders associated with inflammation (5). Microglial P2X7 receptors may contribute to neuroinflammatory responses in the ATP-rich site of neuronal injury (6) and mediate inflammatory pain (7, 8). Association studies demonstrate a possible causal link between P2RX7 gene polymorphisms and susceptibility to bipolar affective disorder and major depressive disorder (9,10). |
| SKU | CSIG-13809S |
|---|---|
| Supplier Part Number | 13809S |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |