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GenScriptHeat Stable FGF-basic, Human1mg
GenScript Heat Stable FGF-basic, Human1mg - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$95.00
Your Price
$95.00
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| NETA PART: | GSCRPT-Z03754-10 |
| MFG.PART: | Z03754-10 |
| UNSPSC: | 12352202 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Human | |
| Protein Construction | Expressed with an N-terminal Met and several site mutations
| |
| Purity | ≥ 95% as analyzed by SDS-PAGE | |
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
| Biological Activity | ED50 < 0.25 ng/ml as determined by a dose-response proliferation assay using 3T3 cells. Based on the ED50, the calculated specific activity is approximately > 4.0 × 106 units/mg. It is recommended to experimentally determine the optimal concentration for each specific application by performing a dose response assay. | |
| Expression System | E.coli | |
| Theoretical Molecular Weight | 17.1 kDa | |
| Apparent Molecular Weight | ~17.1 kDa, on SDS-PAGE under reducing conditions. | |
| Formulation | Lyophilized after extensive dialysis against PBS. | |
| Reconstitution | Before opening, centrifuge the vial briefly to bring the contents to the bottom. Reconstitute the lyophilized powder in PBS up to 100 μg/ml | |
| Storage & Stability | Upon receiving, the lyophilized product remains stable for up to 6 months at lower than -70 °C. Upon reconstitution, the product is stable for up to 1 week at 4 °C or up to 3 months at -20 °C. Avoid repeated freeze-thaw cycles by making single-use aliquots before the solution is stored at -20 °C. |
Background
| Target Background | Heat Stable FGF-basic, Human is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomyocytes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury. |
| Synonyms | Heat Stable FGF-2 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03754-10 |
|---|---|
| Supplier Part Number | Z03754-10 |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |