Revvity HTRF Human Total Cyclin E1 Detection Kit, 500 Assay Points

E-type cyclins play an important role in the transition of quiescent cells into the cell cycle. Two E-type cyclins have been previously described, Cyclin E1 and Cyclin E2. Cyclin E1 is known to activate CDK2 inducing S-phase transition and DNA synthesis associated with mitosis. Overexpression of Cyclin E1 is directly implicated in many cancers.

This kit is compatible with the buffer from Total & phospho-CDK2 kits (‰ 64CDK2TPEG & ‰ 64CDK2Y15PEG), so the same lysate can be used for analyses of the level of Total Cyclin E1, Total CDK2 and CDK2 phospho Tyr15.