Revvity HTRF Human Total Progesterone Receptor Detection Kit, 500 Assay Points

The HTRF Human Progesterone Receptor detection assay monitors the expression of endogenous or overexpressed Progesterone Receptor in various cells. The kit recognizes PRA and PRB isoforms.

Progesterone Receptor (PR) is a nuclear receptor that is activated by progesterone. The hormone crosses the cell membrane and binds to the receptor. After binding, PR homodimerizes, enabling translocation to the nucleus. Coupled with a co-activator, the receptor dimer will be recruited to the Progesterone Response Element (PRE) and induce gene expression leading to proliferation / apoptosis balance. PR expression is modulated by Estrogen Receptor. Therefore, PR is a biomarker commonly used as an indicator of Estrogen Receptor-α function. The MAPK kinase pathway has also been described as having an effect on PR activity through phosphorylation.