Revvity Htrf Human Total Ido1 Detection Kit, 10,000 Assay Points

Revvity the total ido1 cell-based assay provides a convenient and accurate way of detecting total ido1 levels within cells.ido1 (indoleamine 2,3 dioxygenase 1) is the most important rate-limiting enzyme of the kynurenine pathway due to its ability to catalyze the degradation of l-tryptophan (trp) to "kynurenine" metabolites (kyn). trp depletion and kyn production promote immunosuppression by inhibiting cd8+ t effector cells and nk cells. it also increases the activity of cd4+ treg cells and mdscs (myeloid-derived suppressor cells). ido1 also plays a key role in promoting new blood vessel development (angiogenesis).ido1 is overexpressed in different tumor cells and infiltrates immune cells, leading to tumor immune escape and neovascularization.although ido1 inhibitors have been developed to inhibit tryptophan metabolism, these therapies have had limited success in prolonging patient survival. recent efforts have shifted to tpd (targeted protein degradation) of ido1 as a potentially more efficacious therapeutic strategy. - PEMSD (Additional S&H Or Hazmat Fees May Apply)