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Genscript IL-3, Mouse
Genscript IL-3, Mouse - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$95.00
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$95.00
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| NETA PART: | GSCRPT-Z03111-10 |
| MFG.PART: | Z03111-10 |
| UNSPSC: | 41106514 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Mouse | |
| Protein Construction | Expressed with an N-terminal Met.
| |
| Purity | > 95% as analyzed by SDS-PAGE | |
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
| Biological Activity | ED50 < 0.05 ng/ml, measured by a cell proliferation assay using M-NFS-60 cells, corresponding to a specific activity of > 2.0 × 107 units/mg. | |
| Expression System | E. coli | |
| Apparent Molecular Weight | ~15.2 kDa, on SDS-PAGE under non-reducing conditions. | |
| Formulation | Lyophilized after extensive dialysis against PBS. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Interleukin-3 (IL-3) is a pleiotropic cytokine belonging to the interleukin family. IL-3 shares similarities with Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and IL-5: they all have a four-helix bundle structure, are located on the same chromosomes in both human and mouse, are produced by activated T cells, and share receptors. The IL-3/IL-5/GM-CSF receptor family members are all heterodimeric, composed of a receptor-specific α chain and a common β chain. IL-3 is also called multi-colony stimulating factor since it stimulates the development and colony formation of multiple lineages of hematopoietic cells by activating intracellular pathways such as Ras-Raf-ERK and JAK/STAT. IL-3 inhibits apoptosis and promotes cell survival by targeting the anti-apoptotic bcl-2 gene family. |
| Synonyms | IL3; interleukin 3; IL-3; MCGF; MULTI-CSF; Mast cell growth factor; P-cell stimulation factor; HCGF |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03111-10 |
|---|---|
| Supplier Part Number | Z03111-10 |
| UM | EA |
| UNSPSC | 41106514 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |
| Hazardous | N |