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Genscript FGF-18, Rat
Genscript FGF-18, Rat - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$1,625.00
Your Price
$1,625.00
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NETA PART: | GSCRPT-Z03100-1 |
MFG.PART: | Z03100-1 |
UNSPSC: | 41106514 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Rat | |
Protein Construction |
| |
Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC | |
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
Biological Activity | ED50 < 0.5 µg/ml, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2.0 × 103 units/mg. | |
Expression System | E. coli | |
Apparent Molecular Weight | ~20.1 kDa, on SDS-PAGE under non-reducing conditions. | |
Formulation | Lyophilized after extensive dialysis against PBS. | |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. | |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation; FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma. |
Synonyms | FGF18; Fibroblast Growth Factor-18; zFGF5; FGFI |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03100-1 |
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Supplier Part Number | Z03100-1 |
UM | EA |
UNSPSC | 41106514 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |