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AG Scientific Lactacystin, 100 UG
NETA PART: | RPI-L-1147-100UG |
MFG.PART: | L-1147-100UG |
UNSPSC: | 12352200 |
Manufacturer: | AG Scientific |
Lactacystin is a microbial metabolite of Streptomyces strains and acts as a cell permeable, specific, and irreversible inhibitor of 20S proteasome and lysosomal enzyme, Cathepsin A. It irreversibly binds to N-terminal threonine residue on active site of catalytic B subunit of 20S proteasome and therefore blocks proteolytic activity.
The metabolite blocks the cell cycle and induces neurite outgrowth in a murine neuroblastoma cell line, Neuro-2a. It inhibits cell cycle progression in both the G0/G1 and G2/M phases of the cell cycle. Treatment of Lactacystin in Neuro-2a cells displays bipolar morphology and becomes progressively more multipolar.
Lactacystin induces apoptosis in human monoblastic U937, confirming DNA fragmentation.
SKU | RPI-L-1147-100UG |
---|---|
Supplier Part Number | L-1147-100UG |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | AG Scientific |
MSDS URL | https://agscientific.com/system/product_documents/L-1147%2C%20Lactacystin%2C%20SDS%202022_r01_1.pdf |
Temperature | -20°C |
Refrigerated-Frozen | Y |
CountryOfOrigin | Japan |
ProductLine | AG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 5.00 |
Lead Time | 5 Business Days |
Hazardous | N |
CAS Number | 133343-34-7 |