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Cell Signaling Rsk1/Rsk2/Rsk3 (D7a2h) Rabbit mAb
Cell Signaling Rsk1/Rsk2/Rsk3 (D7a2h) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$327.00
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$327.00
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| NETA PART: | CSIG-14813S |
| MFG.PART: | 14813S |
| UNSPSC: | 41116133 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H M R Hm Mk B Dg Pg |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 90 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | RSK1/RSK2/RSK3 (D7A2H) Rabbit mAb recognizes endogenous levels of total RSK1, RSK2, and RSK3 proteins. This antibody is predicted to cross-react with RSK4 but has approximately 100-fold greater affinity for RSK1, RSK2, and RSK3. This antibody does not cross-react with other homologous RSK family members, such as human or mouse MSK1 or MSK2. |
| Species Reactivity | Human, Mouse, Rat, Hamster, Monkey, Bovine, Dog, Pig |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro583 of human RSK1 protein (Pro587 in hRSK2, Pro580 in hRSK3). |
| Background | The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3). |
| SKU | CSIG-14813S |
|---|---|
| Supplier Part Number | 14813S |
| UM | UNIT |
| UNSPSC | 41116133 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |