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Millipore Active, N-Terminal His6-Tagged, Recombinant Amino Acids 2-End Of Human Gsk3α, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal His6-tagged, recombinant amino acids 2-end of human GSK3α
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal His6-tagged, recombinant amino acids 2-end of human GSK3α, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Expressed in Sf21 cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_019884.2
Entrez Gene Summary
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila shaggy (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
Gene Symbol
GSK3A
DKFZp686D0638
Protein Target
GSK3α
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
CMGC
UniProt Number
P49840
UniProt Summary
FUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity). SIZE: 483 amino acids; 50981 Da SUBUNIT: Monomer (By similarity). SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
Molecular Weight
55kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2 (GSK3 Substrate)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
1 year at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-492M - Call for pricing and availability.
