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Purified Neurocan in PBS. Contains no preservative.
Quality Level
MQ100
Applications
Key Applications
Cell Culture
ELISA
Application Notes
Inhibition of cell-cell adhesion, cell-ECM adhesion or cell migration at:
0.1 to 30 micrograms / mL.
ELISA Assay: 0.05 to 5 micrograms / mL
Optimal working concentrations must be determined by the end user.
Biological Information
Concentration
100 μg/mL
Purity
A mix of Chondroitin Sulfate Proteoglycans from chick brain (Chemicon CC117) was purified by the unique density and size of this class of molecules. Neurocan is purified from this mix using an immobilized monoclonal antibody. The resulting neurocan is pure and has chondroitin sulfate attached. Removing the chondroitin sulfate with chondroitinase, results in core proteins are primarily the full-length 250 kD form and a little of smaller neurocan fragments.
Source
Chicken Brain.
Entrez Gene Number
NM_004386.2
Entrez Gene Summary
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM]
Gene Symbol
NCAN
FLJ44681
NEUR
CSPG3
UniProt Number
O14594
UniProt Summary
FUNCTION: SwissProt: O14594 # May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. SIZE: 1321 amino acids; 143093 Da TISSUE SPECIFICITY: Brain. SIMILARITY: SwissProt: O14594 ## Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 2 EGF-like domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 2 Link domains. & Contains 1 Sushi (CCP/SCR) domain.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
