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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | FC, IF, IP, IHC | AHm | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | CBL1345 |
| Brand Family | Chemicon® |
| Trade Name |
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| Description | Anti-Integrin α2 Antibody, clone HMα2 |
| Alternate Names |
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| Background Information | The complex of CD49b associated with CD29 (integrin beta1) is a receptor for laminin and collagen. This complex is expressed by some CD4-positive T cells, natural killer cells, epithelial cells and platelets. |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | The affinity chromatography purified monoclonal is presented in phosphate buffered saline, pH 7.2, containing 0.09% sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Integrin α2 Antibody, clone HMα2 detects level of Integrin α2 & has been published & validated for use in FC, IF, IP, IH. |
| Key Applications |
|
| Application Notes | FlowCytometry: = .5 μg per 10e6 cells in 100 μL volume Immunoprecipitation Immunofluorescence Immunohistochemistry Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Clone | HMalpha2 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Armenian Hamster |
| Specificity | Specifically recognizes the 150 kDa mouse CD49b, also known as Integrin alpha2. |
| Isotype | IgG |
| Species Reactivity |
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| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Entrez Gene Summary | This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. |
| Gene Symbol |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. SIZE: 1181 amino acids; 129295 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C for up to 12 months from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 500 µg |