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of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality Level
MQ100
Applications
Application
This Anti-IKKε Antibody is validated for use in WB for the detection of IKKε.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 582-596 (SHLAKRLLQVFQEEC) of human IKKε
Host
Rabbit
Specificity
IKKε
Isotype
IgG
Species Reactivity
Human
Mouse
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_014002
Gene Symbol
IKBKE
IKKI
MGC125294
IKK-i
IKKE
IKK-epsilon
IkBKE
MGC125295
MGC125297
KIAA0151
Purification Method
Protein A Purfied
UniProt Number
Q14164
UniProt Summary
FUNCTION: SwissProt: Q14164 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. SIZE: 716 amino acids; 80462 Da SUBUNIT: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE. SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon. PTM: Autophosphorylated. SIMILARITY: SwissProt: Q14164 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight
Mr 80kDa
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
