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Description | |
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Catalogue Number | AG374 |
Brand Family | Chemicon® |
Trade Name |
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Description | Metabotropic Glutamate Receptor 5, control peptide for AB5675 |
Overview | Metabotropic Glutamate Receptor 5 (mGluR5) control peptide. |
Alternate Names |
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Product Information | |
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Presentation | Liquid. |
Quality Level | MQ100 |
Applications | |
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Key Applications |
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Application Notes | Antibody blocking (AB5675) Optimal working concentration must be determined by the end user. |
Biological Information | |
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Concentration | 1 mg/mL |
Entrez Gene Number |
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Entrez Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. |
Gene Symbol |
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UniProt Number |
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UniProt Summary | FUNCTION: SwissProt: P41594 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. SIZE: 1212 amino acids; 132469 Da SUBUNIT: The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P41594 ## Belongs to the G-protein coupled receptor 3 family. |
Product Usage Statements | |
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Usage Statement |
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Storage and Shipping Information | |
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Storage Conditions | Store at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. |
Packaging Information | |
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Material Size | 100 µg |