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Cell Signaling C-Iap1 (D5g9) Rabbit mAb
Cell Signaling C-Iap1 (D5g9) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$139.00
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$139.00
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NETA PART: | CSIG-7065T |
MFG.PART: | 7065T |
UNSPSC: | 12352202 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 62 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | c-IAP1 (D5G9) Rabbit mAb recognizes endogenous levels of total c-IAP1 protein. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu28 of human c-IAP1 protein. |
Background | The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2). |
SKU | CSIG-7065T |
---|---|
Supplier Part Number | 7065T |
UM | UNIT |
UNSPSC | 12352202 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |