Cayman 4-Oxo-2-Nonenal-D3; Purity- Greater Than Or Equal To 99% D

4-oxo-2-Nonenal-d₃ (4-ONE-d₃) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.^1,2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.^1,2,3 4-ONE is a more recently identified product of lipid peroxidation.^4,5,6 It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.^7,8 4-ONE also modifies 2-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.¹

WARNING This product is not for human or veterinary use.