Cayman Prostaglandin E2-1-Glyceryl Ester-D5; Purity- Greater Than

Prostaglandin E₂-1-glyceryl ester-d₅ (PGE₂-1-glyceryl ester-d₅) contains five deuterium atoms. It is intended for use as an internal standard for the quantification of PGE₂-1-glyceryl ester by GC- or LC-mass spectrometry. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the central cannabinoid receptor.^, Incubation of 2-AG with cyclooxygenase-2 and specific PGH₂ isomerases in cell cultures and isolated enzyme preparations results in PG glycerol ester formation. The biosynthesis of PGH, PGD, PGE, PGF, and thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.

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