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Cayman Afmk; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-10005254-5 |
MFG.PART: | 10005254-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
CC-115 is a dual inhibitor of mammalian target of rapamycin (mTOR) and DNA protein kinase (DNA-PK; IC50s = 0.021 and 0.013 µM, respectively)., It is selective for mTOR and DNA-PK over PI3Kα, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively). CC-115 inhibits growth in a panel of 123 cancer cell lines, including breast, head and neck, and lung cancer cells (GI50s = 0.015-1.77 µM), and non-homologous end joining (NHEJ) in CAL-51 and MDA-MB-231 breast, PC3 prostate, and HCT116 colon cancer cells (IC50s = 3.15, 2.16, 2.72, and 6.35 µM, respectively). It reduces tumor growth in a PC3 prostate cancer mouse xenograft model when administered at doses of 0.25, 0.5, and 1 mg/kg twice per day.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:10): 0.01 mg/ml
Shipping & Storage Information
SKU | CAYM-10005254-5 |
---|---|
Supplier Part Number | 10005254-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10005254m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 52450-38-1 |