Cayman ()-L-Threo-Pdmp (Hydrochloride); Purity- Greater Than Or E

(–)-L-threo-PDMP is a ceramide analog and one of the four possible stereoisomers of PDMP (Item No. 62595).¹ L-threo-PDMP is an enhancer of ganglioside biosynthesis.^1,2 It increases glucosylceramide synthase activity by 4 and 8% when used at concentrations of 5 and 2.5 µM, respectively, in an enzyme assay.¹ L-threo-PDMP increases the activity of ganglioside GM₃, GD₃, and GQ_1b synthases and increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM₃ in B16 melanoma cells.^2,3 It inhibits the growth of MCF-7, MDA-MB-468, SK-BR-3 cells with IC₅₀ values of 4, 7, and 6 µM, respectively.⁴ L-threo-PDMP increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at a dose of 40 mg/kg per day.² The L-threo-PDMP isomer is the glucosylceramide synthetase stimulatory component of DL-threo-PDMP (Item No. 10005276), while D-threo-PDMP (Item No. 10178) is the inhibitory component.¹ [Matreya, LLC. Catalog No. 1749]

WARNING This product is not for human or veterinary use.