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Cayman Fenofibrate; Purity- Greater Than Or Equal To 98%; Size- 1
NETA PART: | CAYM-10005368-1000 |
MFG.PART: | 10005368-1000 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Bestatin is an aminopeptidase inhibitor originally isolated from S. olivoreticuli. It inhibits aminopeptidase B (IC50 = 0.05 µg/ml), aminopeptidase N (IC50 = 16.9 µM), leucine aminopeptidase (IC50 = 0.01 µg/ml), and the aminopeptidase activity of leukotriene A4 (LTA4) hydrolase (Kapp = 172 nM).,, It is selective for these aminopeptidases over aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, and thermolysin. Bestatin inhibits the production of LTB4 (Item No. ) in erythrocytes when used at a concentration of 70 µM. It increases the expression of Akt, inhibits proliferation, migration, and invasion, and induces autophagy and apoptosis in 5637 bladder cancer cells. Bestatin (5 and 15 mg/kg) decreases serum levels of LTB4 and reduces tumor growth in a patient-derived xenograft (PDX) mouse model of colorectal cancer.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: 2.5 mg/ml
- PBS pH 7.2: 0.15 mg/ml
Shipping & Storage Information
SKU | CAYM-10005368-1000 |
---|---|
Supplier Part Number | 10005368-1000 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10005368m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1000 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 49562-28-9 |