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Cayman 11 Betahydroxysteroid Dehydrogenase (Type 1) Blocking Pe
Cayman 11 Beta -Hydroxysteroid Dehydrogenase (Type 1) Blocking Peptide; Purity- Greater Than 75%; Size- 1 Ea; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$132.00
Your Price
$132.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-10005729-1 |
| MFG.PART: | 10005729-1 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Cytisine is an alkaloid that has been found in C. laburnum. It is a partial agonist of nicotinic acetylcholine receptors (nAChRs) with an EC50 value of approximately 1 µM for increasing current in Xenopus oocytes expressing α4β2 subunit-containing nAChRs. Cytisine (20 nM) inhibits current induced by acetylcholine (Item No. ) by 50% in Xenopus oocytes expressing α4β2-subunit containing nAChRs. It binds to α2β2, α2β4, α3β2, α3β4, α4β2, and α4β4 nAChR subunits expressed in HEK293 cells with Ki values of 1.1, 5.4, 37, 220, 1.5, and 2.1 nM, respectively. Cytisine (3 mg/kg) reduces increases in the intracranial self-stimulation (ICSS) threshold of rats withdrawing from nicotine self-administration, indicating a decrease in the dysphoric state induced by nicotine withdrawal.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R,5S)-
CAS Number
485-35-8
Synonyms
- Baptitoxine
- Cytiton
- Laburnin
- Sophorine
- Tsitafat
Molecular Formula
C11H14N2O
Formula Weight
190.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 1 mg/ml
- PBS (pH 7.2): 10 mg/ml
λmax
234, 309 nm
SMILES
O=C1N2C[C@]3([H])CNC[C@](C3)([H])C2=CC=C1
InChi Code
InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
InChi Key
ANJTVLIZGCUXLD-DTWKUNHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-10005729-1 |
|---|---|
| Supplier Part Number | 10005729-1 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/10005729m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |