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ChREBP (carbohydrate response element-binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NSL) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine-zipper-like (Zip-like) domain. ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney, white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol and upon high glucose stimulation the protein is translocated into the nucleus following its dephosphorylation of phospho-Ser196. Murine ChREBP is 864 amino acids in length with an estimated molecular weight of about 95 kDa. Cayman’s ChREBP polyclonal antibody detects a specific band at 100 kDa in tissues and cells such as liver, white fat, and HepG2 cells.
WARNING This product is not for human or veterinary use.
Technical Information
Synonyms
Carbohydrate Response Element-binding Protein
WBSCR14
Formulation
200 µg of peptide
Storage Buffer
200µl TBS, pH 7.4, with 0.1% BSA and 0.02% sodium azide