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Cayman Arachidonic Acid Quant-Pak; Size- 1 Ea
NETA PART: | CAYM-10006835-1 |
MFG.PART: | 10006835-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Mizolastine is a histamine H1 receptor antagonist (Ki = 0.001 µM). It is selective for histamine H1 over histamine H2 and H3 receptors (Kis = >100 µM for both), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, 5-HT2, and 5-HT3, dopamine D1 and D2, α1- and α2-adrenergic, adenosine, and muscarinic receptors in radioligand binding assays (Kis = >1 µM for all). Mizolastine (0.1, 0.3, and 1 mg/kg) reduces histamine release from bronchial mast cells in ovalbumin-sensitized guinea pigs. It reduces histamine-induced paw edema in rats, skin edema in dogs, and bronchoconstriction in guinea pigs (ED50s = 0.5, 0.07, and 0.03 mg/kg, respectively). Mizolastine also inhibits passive cutaneous anaphylaxis, as well as lethal shock induced by compound 48/80 (Item No. ) in rats (ED50s = 1.6 and 0.07 mg/kg, respectively). Formulations containing mizolastine have been used in the treatment of allergic rhinitis and urticaria.
WARNING This product is not for human or veterinary use.
Technical Information
- SL 850324
- Chloroform: 10 mg/ml
- DMF: slightly soluble
- DMSO: slightly soluble
Shipping & Storage Information
SKU | CAYM-10006835-1 |
---|---|
Supplier Part Number | 10006835-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10006835m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |